The Science Behind the TruAge Test as a DNA Age Predictor
Cells generally chug along, replicating at proper times and leading a regulated existence – all driven by your DNA. But if they mutate, become damaged, or sense danger they can “senesce,” or essentially fall asleep. Alas, this senescent state causes the cells to release cytokines, which encourages bodily inflammation, which is involved in many degenerative and chronic illnesses.
Cells also suffer when the genes that regulate their behavior lose or suffer shortened telomeres, the “caps” on the ends of DNA strands. They may shrink and even disappear when damaged by the environmental insults of toxins, trauma or unhealthy lifestyle choices.
Methylation is the other key process involved in cell disfunction and aging. When methyl groups latch on to DNA, they inhibit gene expression. This process is particularly associated with immune system aging.
So how do you know the state of your cells? That is where the TruAge test offered by Gentera comes in. This test is based on research by scientist Steven Horvath, PhD, who is currently a professor in human genetics and biostatistics at University of California, Beverly Hills. His work demonstrated how to measure biological age via epigenetic changes. The TruAge test can reveal what is happening inside your body more deeply and effectively than any X-ray or MRI.